Перегляд за Автор "Makarenko, Olexandr"

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Synthesis and transformation of 6-aminomethyl derivatives of 7-hydroxy-2-fluoroisoflavones
(2020) Makarenko, Olexandr; Bondarenko, Svetlana; Mrug, Galyna; Frasinyuk, Mihaylo
Mannich aminomethylation of 8-methyl-7-hydroxy-2'-fluoroisoflavones applying bis-(N,N-dimethylamino) methane afforded C-6 substituted N,N-dimethylaminomethyl derivatives. Subsequent acetylation of these compounds in acetic anhydride in the presence of potassium acetate provided access to the corresponding acetoxymethyl derivatives that were converted to hydroxymethyl- and alkoxymethyl-substituted 7-hydroxyisoflavonoids. Addition of 3-(N,N-dimethylamino)-5,5-dimethyl-2-cyclohexen-1-one or 1,3-dimethyl-5-aminopyrazole with thermally generated orthoquinone methides led to hetero-Diels–Alder or Michael adducts