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    Trifluoroacetylation of 2-Methyl- and 2-Ethylchromones: A Convenient Access to 2-Trifluoroacetonyl Chromones
    (2019) Biletska, Iryna; Mrug, Galyna; Frasinyuk, Mihaylo; Bondarenko, Svetlana; Sviripa, Vitaliy
    We elaborated simple and efficient method for the synthesis of 2-(3,3,3-trifluoroacetonyl) chromones and isoflavones. This method involves an initial in situ generation of the vinyl ethers from 2-methyl- or 2-ethylchromones/isoflavones and their subsequent acylation with trifluoroacetic anhydride in the presence of CF3COOK. This pathway provides convenient access to novel fluorinated analogs of naturally occurring chromones with good yield