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Документ Synthesis of homoisoflavonoids with a coumarin moiety and coumarin-pyrazole or coumarin-isoxazole hybrids based on them(2022) Myshko, Nataliia; Mrug, Galyna; Bondarenko, Svetlana; Frasinyuk, MihayloIn this research in the oxa-Diels–Alder reaction of thermally generated ortho-quinone methides from 3-aryl-8-(N,N-dimethylaminomethyl)coumarines with (2E)-3-(N,N-dimethylamino)-1-(2-hydroxyphenyl)prop-2-en-1-ones and the subsequent cascade of reactions were obtained 8-[4-oxo-4H-chromen-3-yl)methyl]-7-hydroxy-3-phenyl-2H-chromen-2-ones. Synthesis of pyrazole-3-arylcoumarin hybrids was performed by recyclization of chromone core of homoisoflavonоids under hydrazine actions. Target isoxazoles were synthesized by the reaction of homoisoflavonоids with hydroxylamine hydrochloride in ethanol in presence of DBUДокумент One-Pot Synthesis of B-Ring ortho-Hydroxylated Homoisoflavonoids(2019) Myshko, Nataliia; Bondarenko, Svetlana; Mrug, Galyna; Sviripa, Vitaliy; Frasinyuk, MihayloA reliable method for the synthesis of B-ring hydroxylated homoisoflavonoids and 3-hetarylmethyl chromones has been developed. The method involves an initial oxa-Diels-Alder reaction of ortho-quinone methides generated from aryl/hetaryl-substituted ortho-(N,N-dimethylaminomethyl)phenols with (2E)-3-(N,N-dimethylamino)-1-(2-hydroxyphenyl)-prop-2-en-1-ones and the subsequent cascade of reactions. This synthetic strategy avoids conventional multistep protocols and does not require the protection of hydroxyl groups, thus allowing the facile synthesis of a library of various aromatic and heterocyclic analogs of naturally occurring homoisoflavonoids