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Документ Bacteriocins Lactobacillus – an alternative to antimicrobial drugs(2021) Voloshina, Iryna; Soloshenko, Kateryna; Krasinko, Victoria; Lych (Tkachenko), Inna; Shkotova, LyudmilaThe review presents the characteristics of bacteria of the Lactobacillus family and their ability to synthesize various bacteriocins. The classification of lactobacilli bacteriocins is given, which includes three classes: class I – lantibiotics (peptides with a molecular weight of less than 5 kDa, which containing lanthionine), class II – unmodified bacteriocins, also called non-lantibiotics (heat-resistant peptides, which do not contain lanthionine and have a molecular weight of less 10 kDa) and class III – a poorly studied group of thermolabile proteins with a molecular weight of more than 30 kDa. Lactobacilli are shown to synthesize a wide spectrum of bacteriocins, which demonstrate a variety of actions and are able to inhibit the growth of numerous species of opportunistic gram-positive microflora. The article also provides the examples of lactobacilli bacteriocins isolated from food products (fermented meat, fish, kombucha, goat milk, koumiss, etc.) and various human biotopes (microbiota of breast milk, intestinal tract, and vaginal secretions). Additionally, the review shows the prospects of wide application of bacteriocins synthesized by lactobacilli in the food and pharmaceutical industries.Документ Determination of molecular weights of biologically active fragments of colostrum by electrophoresis method(2017) Lych (Tkachenko), Inna; Veriovka, Serhii; Voloshina, IrynaIt has been determined that high molecular weight fractions of colostrum contain protein molecules with molecular weights of 160-190 kDa, among which are immunoglobulins. Separate parts of immunoglobulins and other proteins, namely, IgG (55kDa) and IgA (62kDa) heavy chains, secretory component of sIgA, and lactoferrin, have also been found out. The test samples of high molecular weight peptides of colostrum contain the biologically active fragments among which there are mostly immunoglobulins, their parts, proteinsabzymes, other protein fragments. The proteins with the molecular weight of 80, 62, 55 kDa are also determined, they can represent heavy chains (55 kDa) and light chains (25 kDa) of IgG and sIgA. In particular, sIgA is a supermolecular complex consisting of Н- and L-chains of IgA (62, 25 kDa, respectively) and a secretory component (80 kDa). Apart from the secretory component of IgA, the protein molecules with the molecular weight of 80 kDa can be halves of the molecules of immunoglobulins or lactoferrin.Документ Practical use of goat milk and colostrum(2021) Voloshina, Iryna; Soloshenko, Kateryna; Lych (Tkachenko), Inna; Shkotova, LyudmilaThis review presents the protein and amino acid composition of both goat colostrums and milk and describes the properties of goat colostrums and milk components. In addition, the prospects of use of goat milk and colostrum in the food and cosmetics industry and the feasibility of use of goat milk for baby feeding are shown. Functional foods produced from goat milk have antioxidant, anti-inflammatory, cardioprotective, antihypertensive and antiatherogenic activities in the human body. Goat milk cosmetics are very useful for maintaining a healthy skin and are effective in treatment of various skin diseases. Infant formula based on goat milk provides comfortable digestion for babies and are better at absorbing proteins, fats and other nutrients than infant formula based on cow’s milk.Документ Polyfunctional properties of goat colostrum proteins and their use(2020) Soloshenko, Kateryna; Lych (Tkachenko), Inna; Voloshina, Iryna; Shkotova, LyudmilaThe review presents the composition of goat colostrum, antimicrobial, immunomodulatory and antioxidant properties of biologically active proteins of goat colostrum, as well as the prospects of their use in medicine. Due to the presence of a complex of biologically active proteins such as lactoferrin, lysozyme, lactoperoxidase, immunoglobulins, etc., goat colostrum increases the body’s resistance to infectious diseases, strengthens the immune system, has an antioxidant effect and antibacterial activity against a wide range of microorganisms, thereby preventing or delaying chronic diseases associated with the oxidative stress. Additionally, goat colostrum bioactive proteins show antitumor activity, antiatherogenic properties, the ability to lower the blood pressure and efficiency in the treatment of rheumatoid arthritis.Документ Screening adjuvants organic and inorganic nature for constructing cancer vaccines(2012) Babiy, O.; Gregirchak, Natalia; Lych (Tkachenko), Inna; Shpak, E.On іntaktnih tvarinah vivchali іmunomodulyuyuchu aktivnіst the heterologous vaccine vigotovlenih on osnovі Kuryachii embrіonalnih bіlkіv that a'dyuvantіv organіchnoї that neorganіchnoї nature. Vstanovleno scho naybіlshim іmunologіchno Activity ad'yuvantami stvorennya for the heterologous vaccine protipuhlinnih Yea glіkoproteїdi B. subtilis B-7025 s MM 18.5 kDa that 70 kDa. Spectrum іmunologіchnih efektіv doslіdzhuvanih vaccines include aktivuyuchy vpliv on klіtinnі i gumoralnі reaktsії adaptive іmunіtetu (aktivnіst CTL spetsifіchna tsitotoksichnіst sirovatki krovі) that on reaktsії prirodnoї protipuhlinnoї rezistentnostі (cytotoxic aktivnіst Lf i Matt). Results of the work yavlyayutsya basis for doslіdzhen away vplivu vaccines humoral Lanka іmunіtetu that mozhlivostі stvorennya protipuhlinnih preparatіv on osnovі danih glіkoproteїdіv that Kuryachii embrіonalnih bіlkіv.Документ Immunotherapeutic approaches in the treatment of herpetic infections(2012) Skrotska, Oksana; Lych (Tkachenko), Inna; Solominchuk, V.; Zholobak, NadezhdaThe possible consequences of human infecting by Herpesviridae are shown. The basic classes of preparations used in Ukraine for the immunotherapy of Herpesviridae infections, in particular interferons, inductors of interferons and immunomodulators are described. The comparative description these preparations and their advantages and disadvantages are presented.