Electron-Rich Amino Heterocycles for Regiospecific Synthesis of Trifluoromethyl-Containing Fused Pyridines

Volochnyuk, DmitriyPushechnikov, AlexeiKrotko, DmitriySibgatulin, DmitriyKovaleva, SvetlanaTolmachev, Andrei2014-12-252014-12-252003Electrophilic aromatic substitutions, annulations, heterocycles, pyridines, fluorine / D. M. Volochnyuk, A. O. Pushechnikov, D. G. Krotko and other // Synthesis. – 2003. – № 10. – Р. 1531–1540.https://dspace.nuft.edu.ua/handle/123456789/19348The reaction of 4,4,4-trifluoro-3-oxobutanoates with the corresponding electron-rich amino heterocycles was investigated. A simple and flexible general procedure for the regiospecific annulation of the trifluoromethylpyridine ring to electron-rich amino heterocycles was proposed. A set of CF3-containing fused pyridines in almost quantitative yield was obtained.электрофильное замещениеаннелированиегетероциклыпиридинфторелектрофільне заміщенняанелюваннягетероциклипіридиниelectrophilic substitutionannulations, heterocyclespyridinesfluorineкафедра харчової хіміїElectron-Rich Amino Heterocycles for Regiospecific Synthesis of Trifluoromethyl-Containing Fused PyridinesArticle