Please use this identifier to cite or link to this item: http://dspace.nuft.edu.ua/jspui/handle/123456789/8003
Title: A possible general mechanism of the signal transfer on the α/β-interferons expression. 1. The local cell membrane deformation as the first induction stage
Authors: Karpov, Alexander
Keywords: інтерферон
індуктор
віруси поліаніони
дволанцюгова РНК
інтеркалятори
interferon
inducer
viruses polyanions
double-stranded RNA
intercalators
кафедра біотехнології і мікробіології
Issue Date: 1998
Citation: Karpov, O. A possible general mechanism of the signal transfer on the α/β-interferons expression. 1. The local cell membrane deformation as the first induction stage / O. Karpov // Біополімери і клітина. – 1998. – Т.14, №6. – С. 561-566.
Abstract: A hypothetic mechanism of the external effect of viruses, synthetic polyaniones, double-stranded RNAs, and synthetic double-stranded polyribonucleotides upon a cell is explained. This effect is known to be followed by the α/β-interferons induction. Double-stranded RNAs and polynucleotides inducing such process are thought to change their conformation in an outer ionic perimembrane layer of cells and to induce the specific local deformation of cell membranes giving a signal for the α/β-interferons induction. In the case of viruses such a membrane deformation appears on the stage of virus penetration into the cell. The α/β-interferons inducers of intercalating nature are proposed to cause the interferonogenesis in vivo forming complexes with exogenic RNA molecules and stabilizing their double-stranded sites with a partial complementarity.
URI: http://dspace.nuft.edu.ua/jspui/handle/123456789/8003
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