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Документ Reaction of ortho-Quinone Methides with Amphiphilic Nucleophiles(2023) Myshko, Andrii; Mrug, Galyna; Myshko, Ivan; Bondarenko, Svetlana; Frasinyuk, MihayloIn continuing our studies on flavonoid-like scaffolds as privileged structures in medicinal chemistry, we studied the reaction of isoflavonoid derivatives with amphiphilic nucleophiles with heterocyclic cores. The direction of the reaction significantly depends on starting phenols, nucleophiles, and reaction conditions. Thus, applying phenolic Mannich bases led to formation of isoflavone-heterocycle hybrid via thermal formation of ortho-quinone methides in aprotic solvents and subsequent Michael addition