Перегляд за Автор "Timoshok, Natalia"

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Aspects of influence of Lactobacillus and Bifidobacterium on interferonogenesis and phagocytic cells activity
(2009) Spivak, Mykola; Pidgorsky, Valentin; Lazarenko, Lyudmila; Shynkarenko, Lyubov; Olevinska, Zoya; Timoshok, Natalia; Starovoitova, Svitlana
The introduction of Bifidobacterium bifidum, Bifidobacterium longum, Lactobacillus acidofilus, Lactobacillus casei or Lactobacillus bulgaricus to mice was accompanied by increase of functional activity of phagocytosis system cells proved by stimulation of oxygen-depending bactericide and absorbing activity of peritoneal macrophages. As our date testifies the composition on the basis of Bifidobacterium bifidum, Bifidobacterium longum, Lactobacillus acidofilus, Lactobacillus casei or Lactobacillus bulgaricus is the most perspective for probioticoimmunotherapy.
Cholesterol-lowering activity of lactic acid bacteria probiotic strains in vivo
(2012) Starovoitova, Svitlana; Babenko, Lidia; Timoshok, Natalia; Shynkarenko, Lyubov; Lazarenko, Lyudmila; Spivak, Mykola
Cholesterol-lowering activity of probiotic strains of lactic acid bacteria genera Lactobacillus and Bifidobacterium in the in vivo experiments on the model of experimental hypercholesterolemia in mice was studied. It is established that the prophylactic scheme of introduction of probiotic cultures is more effective than therapeutic one for the manifestation of cholesterase activity of probiotic cultures. The most effective were the cultures: L. acidophilus and B. bifidum, as well as the composition B. bifidum + B. longum. Cholesterol-lowering activity of the studied strains and their compositions in this experiment ranged between 40-78%. It is noted that cholesterase activity of other studied strains was not lower, and in some cases, higher than that of most of the drugs currently used in cholesterinosis.
Herpetical infection in mice and protective activity the composition of lactobacteria
(2010) Timoshok, Natalia; Starovoitova, Svitlana; Shy, D.; Shevchuk, V.; Spivak, Mykola
The protective activity of the lactobacteria composition under herpetic meningo-encephalitis connected with endogenic interferon stimulation during the whole terms of observation was 6 days. Thus, introducing of lactobacteria composition permitted to increase mice splenocytes activity, so they induced more interferon –α and –γ in vitro in response to an adequate induction. Thus, is has been revealed the significant efficacy of lactobacteria composition use on the model of mice herpetic meningo-encephalitis, which was stipulated activation by the system of interferon control animals.
Immunomodulating activity of lactic acid bacteria and bacillus microorganisms on experimental models
(2010) Shynkarenko, Sichel; Timoshok, Natalia; Lazarenko, Lyudmila; Starovoitova, Svitlana; Spivak, Mykola
One approach for the creation of highperformance probiotic preparations is a comparative study of their immunomodulating activity in experiments in vitro and in vivo.
Influence of Lactobacillus and Bifidobacterium on interferonogenesis and phagocytic cells activity
(2009) Spivak, Mykola; Pidgorsky, Valentin; Lazarenko, Lyudmila; Shynkarenko, Lyubov; Rachkova, L. T.; Olevinska, Zoya; Timoshok, Natalia; Starovoitova, Svitlana
It was established that Bifidobacterium bifidum, Bifidobacterium longum, Lactobacillus acidofilus, Lactobacillus casei, Lactobacillus bulgaricus as well as standard interferon inducer ridostine in vivo had activating influence on production of endogenous interferon that proved to be true by essential increase of interferon titer in blood serum of mice during 6 days. For 12 days the interferon titer in blood serum did not exceed a control value. Lactobacillus acidofilus and Bifidobacterium longum have appeared the most effective inducing agent of both “early” and “late” interferon. The simultaneous injection of Bifidobacterium bifidum, Bifidobacterium longum, Lactobacillus acidofilus, Lactobacillus casei, Lactobacillus bulgaricus led to more significant increase of interferon titer in mic blood serum comparing with the influence of the single strain.