Investigation the process of superfine grinding of components of pharmaceutical and cosmetic products on the bead mill

Abstract

The process of grinding the components of pharmaceutical and cosmetic preparations in a bead mill is considered. The degree of grinding was measured with a "Klin" grindometer, the temperature was measured by a contactless pyrometer, the power was measured by current clamps. The smaller the particle size and the higher density of the suspension, the greater the energy required to conduct the process, and the more heat will be released. When grinding titanium dioxide over a period of 0 to 30 minutes, the power increases from 205 to 209 W, with the most intensive increase observed in the interval from 5 to 10 minutes at 2.33 W. In addition, the temperature of the suspension increases from 21.9 to 23.4 °C, the density of the suspension increases from 889 to 1176 kg/m3, and the particle size decreases from more than 100 μm to 10 μm, the most intensive grinding in the first 5 minutes of the process. When the quinacridone red Red 122 is grinded, the power is increased from 205 to 210 W, the slurry temperature is from 22.4 to 24.3 °C, the density is from 870 to 952 kg/m3, and the particle size decreases from more than 60 μm to 2 μm, while the most intensive grinding occurs in the first 5 minutes of the process.