Ethylthiosulfanilate effect on Candida tropicalis

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dc.contributor.authorOriabinska, Larisa
dc.contributor.authorStarovoitova, Svitlana
dc.contributor.authorVasylyuk, Sofiia
dc.contributor.authorNovikov, Volodymyr
dc.contributor.authorLubenets, Vira
dc.date.accessioned2018-11-05T10:55:19Z
dc.date.available2018-11-05T10:55:19Z
dc.date.issued2017
dc.description.abstractThe problem of resistance of microorganisms to antibiotics stimulates the search for new chemotherapy drugs. Ethylthiosulfanilate (ET S, S-ethyl 4-amino-benzenesulfonothioate, S-ethyl ester of 4-aminobenzenethiosulfoacid) as a structural analog of a number of phytoncides was synthesized based on thiosulfoacid salts. ET S effect on opportunistic yeast fungi Candida tropicalis was studied. It was shown that ET S in subfungicidal concentration (125 μg/ml) affected some aspects of a constructive and energy metabolism of fungi: inhibited endogenous respiration and reduced the pool of nucleic acids. Additionaly the significant changes in lipogenesis of C. tropicalis were detected. It was established that ET S in fungistatic and subfungicidal concentrations possessed membranotropic effect and provided a high degree of cooperativity of structural transitions of membranes.uk_UA
dc.identifier.urihttps://dspace.nuft.edu.ua/handle/123456789/28448
dc.language.isoenuk_UA
dc.publisherEthylthiosulfanilate effect on Candida tropicalis / L. B. Oriabinska, S. O. Starovoitova, S. V. Vasylyuk, V. P. Novikov , V. I. Lubenets // Ukr. Biochem. J. – 2017. – Vol. 89, № 5. – P. 70–76.uk_UA
dc.subjectCandida tropicalisuk_UA
dc.subjectantimycotic actionuk_UA
dc.subjectethylthiosulfanilateuk_UA
dc.subjectкафедра біотехнології і мікробіологіїuk_UA
dc.subjectCandida tropicalisuk_UA
dc.subjectпротигрибкова діяuk_UA
dc.subjectетілтіосулфанілатuk_UA
dc.subjectCandida tropicalisuk_UA
dc.subjectпротивогрибковое действиеuk_UA
dc.subjectэтилтиосульфанилатuk_UA
dc.titleEthylthiosulfanilate effect on Candida tropicalisuk_UA
dc.typeArticleuk_UA

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