Перегляд за Автор "Kondratyuk, K. M."

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Chain-chain tautomerism of ω-aminoalcohol aminomethyl derivatives
(2018) Danylchenko, V. Ye.; Bondarenko, Svetlana; Mrug, Galyna; Kondratyuk, K. M.; Frasinyuk, Mihaylo
The aminomethylation reaction of 2-naphtol, umbelliferon, and 7- hydroxyisoflavones using ω -aminoalcohols and paraformaldehyde was studied. The products of reaction exist as tautomeric mixtures which was confirmed by 2D NOESY spectra. The ratio of tautomers depends on carbon chain length of ω-aminoalcohol, solvent, and pH. The major form of 2-aminoethanol derivatives is 1,3-benzoxazine. However, low-polar solvents shift equilibrium toward 1,3-oxazoline form. Derivatives of 3-aminopropanol are preferably exist as 1,3-oxazoline form in all solvents. The mixture of tautomers also was indicated for 4-aminobutanol derivatives, but 5-aminopentanol derivatives exist only in 1,3- benzoxazine form