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Документ From production to regulation: the comprehensive role of hyaluronic acid in the food and cosmetic industry(2024) Starovoitova, Svitlana; Hryshchenko, MarynaHyaluronic acid (HA) is now approved as a food additive in many countries of Europe, Asia and America and is used as an important element in the food industry. Also, HA is one of the most popular cosmetic ingredients. The aim of this research was to review the comprehensive role of hyaluronic acid in the food industry, from production methods to regulatory aspects. Materials and methods. The study utilized international and domestic scientific publications from leading periodicals and specialized global journals, focusing on hyaluronic acid applications in the food and cosmetic industry and suitable producers. Scientific articles were sourced using global scientometric databases such as Google Scholar and PubMed. Results and discussion. The review revealed that hyaluronic acid has broad applications in the food industry, including as a modifier for dairy and starch-based products, a natural flavor enhancer, and a salt reducer. In the cosmetic industry, HA is used as an anti-aging component that promotes skin hydration. Various microbial strains for HA production were compared, with Corynebacterium glutamicum showing the highest yield (32 g/l over 60 hours). Moreover, international regulations are essential in ensuring the quality and safety of HA-containing products. In the European Union, Regulation (EC) No 1223/2009 sets the standards for the use of hyaluronic acid in cosmetic products, outlining guidelines for product safety, labeling, and permissible concentrations. Globally, HA used in cosmetics and food products must comply with various international standards such as the Codex Alimentarius, which governs food additives, and the ISO 22716:2007 for Good Manufacturing Practices (GMP) in cosmetics production, ensuring consistency in product quality and consumer safety Conclusions. Hyaluronic acid presents significant potential for use in the food and cosmetic industry, with promising production methods using GRAS-status (Generally Recognized As Safe) microorganisms. Adherence to regulatory requirements is crucial for manufacturers and importers of HAcontaining products. Further development of the regulatory framework is expected as technologies and research in HA application continue to advance.