Biosynthesis of silver nanoparticles by Saccharomyces cerevisiae M437

Abstract

Silver nanoparticles (AgNPs) are widely used in medicine and pharmaceuticals as biosensors, diagnostic agents, targeted drug delivery agents with controlled release, as antimicrobial, and anticancer agents. AgNPs are mainly produced by chemical synthesis. The disadvantages of this method: the use of toxic substances (ethylene glycol, hydrazine, and sodium borohydride), low yield of nanoparticles, expensive isolation, and purification. Therefore, it is important to find a safe and effective synthesis method, for example using green synthesis. Biosynthesis can provide a high yield of particles stabilized by natural substances that have high biocompatibility. Biological synthesis can take place both intracellular and extracellular. Cell extracts can also be used for biosynthesis. In this study, the purpose was to synthesize silver nanoparticles using metabolites contained in the supernatant of Saccharomyces cerevisiae M437.