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Документ 2-Acylthioamides in the Biginelli reaction(2017) Simurova, Natalia; Mayboroda, Elena; Britsun, VasiliyДокумент A study of the viscosity of water solutions of inulin – the functional food ingredient(2016) Zinchenko, Natalia; Simurova, Natalia; Shelakov, AndreiInulin is a perspective ingredient for the production of dietary, functional low fat and low sugar foods with improved structure, stability and taste sensations. To ensure product’s balanced nutritional profile and excellent taste properties, it is necessary to carry out a thorough study of physicochemical properties of the ingredients, especially their viscosity. The viscosity of diluted water solutions of inulin, extracted from tubers of Jerusalem artichoke, were examined. Kinematic, relative and specific viscosity was measured by a usual method using viscosimeter.Документ Antiviral activity of 1,2,4-triazole derivatives (microreview)(2021) Simurova, Natalia; Mayboroda, ElenaToday, 1,2,4-triazole derivatives are the preferred structural moieties in the development of new drugs with a wide range of pharmacological activity, as evidenced by several reviews.This is due to the fact that the triazole ring can be considered a bioisostere of an amide, ester, or carboxyl groups. Relatively low toxicity, good pharmacokinetic and pharmacodynamic properties of triazole, its resistance to metabolic degradation are another advantages. In recent years, against the background of the emergence of new viral infections and the lack of effective chemotherapeutic agents for their treatment, the number of studies on the antiviral properties of 1,2,4-triazole derivatives has significantly increased. In the presented review, we focused on current publications devoted to the study of the antiviral properties of compounds containing the 1,2,4-triazole ring. Isosteric analogs of known drugs, as well as new molecules, are considered.Документ Biginelli reaction – an effective method for the synthesis of dihydropyrimidine derivatives(2017) Simurova, Natalia; Mayboroda, ElenaA brief review of the publications over the past 5 years devoted to the synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives using Biginelli reaction is presented. The impact of reaction conditions (solvents, catalysts) on the yield is discussed. New combinations of reagents enabling the synthesis of a wide range of 3,4-dihydropyrimidin-2(1H)-one derivatives with various functional groups are considered.Документ Bioorganic complex derived from Jerusalem artichoke puree(2013) Zinchenko, Natalia; Simurova, NataliaThe composition puree obtained from artichoke. It is shown that it contains a unique complex carbohydrates and other biologically active compounds: organic acids, vitamins, micro and macroelements.Досліджено склад пюре з бульб топінамбуру. Показано, що воно містить унікальний комплекс вуглеводневих та інших біологічно-активних речовин: органічних кислот, вітамінів, мікро- та макроелементів.Документ Iodine insufficiency as a dietary issue in elderly people and its connection with pathology of thyroid(2016) Simurova, Natalia; Postol, Svitlana; Kravchenko, VictorPathologies, that may develop due to microelement insufficiency, are very variable and connected to low synthesis of thyroid hormones. Eldery people start experience some health problems. And among other, problems with thyroid are playing very important role that shouldn’t be ignored. 53 patients in the age of 40-78 years were involved in the research. The easiest and the most effective way to compensate insufficient supply of iodine is regular intake of the iodized salt. Патології, які можуть розвинутися через недостатність мікроелементів, різноманітні і пов'язані з недостатнім рівнем гормонів щитовидної залози. Люди похилого віку починають відчувати все більше проблем зі здоров'ям. І серед іншого, проблеми з щитовидною залозою відіграють дуже важливу роль, яку не можна ігнорувати. У дослідженні брали участь 53 пацієнти віком 40-78 років. Найпростіший і ефективний спосіб компенсувати нестачу йоду - регулярне споживання йодованої солі.Документ Modification of Potato Starch by Acetylmalic Acid Chloroanhydride and Physicochemical Research of the New Product(2018) Shulga, Oksana; Simurova, Natalia; Shulga, Sergii; Smirnova, ElizabethThe article presents the research results of the product’s properties of potato starch modification by acetylmalic acid chloroanhydride. Modification of potato starch has been carried out and has been confirmed by elemental analysis. In the infrared spectra, changes in the frequency oscillations of native starch in the noncharacteristic region have occurred: the frequency of oscillations at 981.81 cm−1 has increased and in the spectrum of modified starch has been at 1024.82 cm−1; the band with frequency of oscillations of 923.07 cm−1 has shifted to 866.66 cm−1, and the band with frequency of oscillations of 609.79 cm−1 has shifted to 672.22 cm−1, indicating the change in noncharacteristic region of the native starch sample after acylation. The properties of obtained modified product have been studied and this modification has appeared to change the shape of moisture and starch bonds, along with decreasing appearance of grains and reduced degree of crystallinity from 12 to 4%.Документ Modification of potato starch with adipic acid and research of modification product as raw materials for food biodegradable packaging(2021) Shulga, Sergii; Shulga, Oksana; Simurova, NataliaThe aim of our work was to study the modification of potato starch with adipic acid chloride in order to further physicochemical study of the obtained product and use, for example, as an effective film former of biodegradable films/coatings. The modified product has a number of different characteristics from the original product. The use of starch as a natural substance that is capable of biodegradation makes it possible to is recommend the resulting product as a raw material for environmentally friendly packaging materials.Документ Multigram Synthesis of trans-2-(Trifluoromethyl)cyclopropanamine(2011) Bezdudnyy, Andrey; Klyukovskyy, Denis; Simurova, Natalia; Mykhailyuk, Pavel; Shishkin, Oleg; Pustovit, Yuriy2-(Trifluoromethyl)cyclopropanamine was synthesized. The key step of the synthesis is a transformation of the carboxy group into the trifluoromethyl group by using sulfur tetrafluoride. Twenty gram of the target product was conveniently prepared in a single batch.Документ Syntheses of 4-aryl-1-R2-6-R1-5-(N-arylthiocarbamoyl)-1,2,3,4-tеtrahydropyrimidine-2-ones (thiones)(2016) Mayboroda, Elena; Simurova, NataliaIt was found that 2-acylthioacetamides enter into Biginelli reaction with aromatic aldehydes and ureas / thioureas with formation of 4-aryl-1-R2-6-R1-5-(N-Aryl-thiocarbamoyl)-1,2,3,4-tetrahydropyrimidine-2-ones(thiones). When exposed to K3[Fe(CN)6] in alkaline environment, 4-aryl-5-(benzothiazole-2'-yl)-1-R2-6-R1-1,2,3,4-tetrahydropyrimidine-2-ones (thiones), and 4-aryl-1-R2-6-R1-5-(N-Ary1-carbamoyl)-1,2,3,4-tetrahydropyrimidine-2-ones (thions) are unexpected products of interaction. Було з'ясовано, що 2-ацилтіоацетаміди вступають в реакцію Біджинеллі з ароматичними альдегідами і сечовинами/тіосечовинами з утворенням 4-арил-1-R2-6-R1-5-(N-Ar1-тіокарбамоїл)-1,2,3,4-тетрагідропіримідин-2-онів(тіонів). При дії на них K3[Fe(CN)6] в лужному середовищі продуктами взаємодії є не очікувані 4-арил-5-(бензтіазол-2'-іл)-1-R2-6-R1-1,2,3,4-тетрагідропіримідин-2-они(тіони), а 4-арил-1-R2-6-R1-5-(N-Ar1-карбамоїл)-1,2,3,4-тетрагідропіримідин-2-они(тіони). Было установлено, что 2-ацилтиоамиды вступают в реакцию Биджинелли с ароматическими альдегидами и мочевиной/тиомочевиной с образованием 4-арил-1-R2-6-R1-5-(N-арил-тиокарбамоил)-1,2,3,4- тетрагидропиримидидин-2-онов (тионов). При воздействии на них K3[Fe(CN)6] в щелочной среде продуктами взаимодействия являются не ожидаемые 4-арил-5-(бензтиазол-2'-ил)-1-R2-6-R1-1,2,3,4-тетрагидропиримидин-2-оны(тионы), а 4-арил-1-R2-6-R1-5-(N-Ar1-карбамоил)-1,2,3,4-тетрагидропиримидин-2-оны(тионы).Документ Synthesis and study of 3-methyI-6H-indolo[2.3-h]quinoxalines(2016) Simurova, Natalia; Shulga, Sergii; Shulga, OksanaPreviously unknown indolo [2,3-b] quinoxaline carbaldehydes and indolo quinoxaline amines have been obtained by condensation of alkylisatins and benzoylisatin with 4 -methylbenzene-1,2-diamine in the medium of glacial acetic acid. The reaction was found to proceed selectively.Документ Synthesis of Dihydropyrimidine Derivatives by Biginelli's Reaction in student Workshops on Organic Chemistry(2017) Simurova, Natalia; Kovaleva, Svetlana; Mazur, LarisaIn classical student workshops, the attention paid to the synthesis of heterocyclic compounds is very little. This is due to the complexity and duration of most of these syntheses, the low availability of the initial reagents, the difficult isolation and purification the reaction products. Biginelli's reaction, as a method of synthesis of dihydropyrimidones, is attractive to be used in the student workshop on chemistry due to the simple procedure of synthesis, as well as a possibility to vary the reaction conditions and select initial reagents to introduce substituents that may be easily transformed to various functional groups.. Students cannot only get acquainted with the basic experimental methods, but also learn how to apply theoretical knowledge in practice, including monitoring of reactions and analyzing organic compounds by physico-chemical methods.Документ Synthesis of N-alkyl-N-heterylmethyl pentenamides as novel neonicotinoid analogs(2019) Simurova, NataliaДокумент Synthesis of Six-Membered Thiophene-Annelated Heterocycle Containing P and N atoms(2017) Kovaleva, Svetlana; Simurova, Natalia; Mazur, LarisaДокумент The analisis of interaction monosaccharides with aminoacides in food row by quantum-chemical methods(2020) Popova, Inna; Mayboroda, Elena; Simurova, Natalia; Karmashov, OleksandrThe object of research is the products of hydrolysis of the polysaccharide inulin (glucose, fructose) of plant raw materials used for the production of food products for health-improving and prophylactic purposes. The search for optimal conditions for the transformation of polysaccharides in the processes of hydrolytic cleavage into fructose-oligosaccharide products requires a thorough study of both the chemical composition of the raw material and the interaction between the components. This affects both the stability of the initial, intermediate and final products of the hydrolysis of the polysaccharide, and its release from plant materials and the further course of its fragmentation. Literature data indicate that the chemical composition of carbohydrate-containing plant materials, in particular the content of mineral components, has not yet been fully studied and requires additional research and refinement. After all, macro- and microelements in its composition are not only important nutrients, but can also take an active part in the transformation of organic components through complexation at intermediate stages of these processes. In addition, the question of the possible interaction of organic compounds in the composition of food raw materials, in particular biopolymers, which make up a significant part of the mass – carbohydrates and protein compounds, also requires attention. Such interaction under normal conditions has practically not been studied, but it can affect the course of technological processes of processing. The study of intermolecular interac-tions occurring in complex natural systems is often complicated either by the absence of direct (selective) physical and physicochemical research methods, or by the multicomponent chemical composition of the system, or by the complexity of the objects (substances) of the study themselves. This is especially true for natural substances of a polymeric nature – proteins, peptides, poly- and oligosaccharides. Therefore, the work paid special attention to the study of the interaction of these components. The spatial structure of inulin molecules, oligosaccharides and elementary units of these polymers has been investigated using quantum chemical modeling. The distribution of ef-fective charges on carbohydrate atoms is calculated; it directly affects their reactivity. And also quantum-chemical models of the interaction of protein substances of plant materials with carbohydrates in vacuum and in aqueous solutions are created, depending on their dilution.