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Документ Cholesteraze activity of new lacto- and bifidobacteria strains in vitro(2010) Starovoitova, Svitlana; Kishko, K.; Lazarenko, Lyudmila; Shynkarenko, Lyubov; Spivak, Mykola; Nikolaychuk, M.Cholesteraze activity of new strains of lacto- and bifidobacteria was studied. It was demonstrated that all strains of lаcto- and bifidobаcteriа in vitro posess different levels of cholesteraze activity. Lactobacillus casei VK-4 IMV B-7280 proved to be the most effective strain. Results of research on cholesteraze activity of different lacto- and bifidobacteria strain compositions showed that the most active combinations are those based on Lactobacillus casei and one of other studied strains of lacto- and bifidobacteria, as well as Bifidobacterium longum and Bifidobacterium bifidum. The studied bacterial strains and also compositions on their basis can be used to create complex probiotics for special purposes.Документ Cholesterol-lowering activity of lactic acid bacteria probiotic strains in vivo(2012) Starovoitova, Svitlana; Babenko, Lidia; Timoshok, Natalia; Shynkarenko, Lyubov; Lazarenko, Lyudmila; Spivak, MykolaCholesterol-lowering activity of probiotic strains of lactic acid bacteria genera Lactobacillus and Bifidobacterium in the in vivo experiments on the model of experimental hypercholesterolemia in mice was studied. It is established that the prophylactic scheme of introduction of probiotic cultures is more effective than therapeutic one for the manifestation of cholesterase activity of probiotic cultures. The most effective were the cultures: L. acidophilus and B. bifidum, as well as the composition B. bifidum + B. longum. Cholesterol-lowering activity of the studied strains and their compositions in this experiment ranged between 40-78%. It is noted that cholesterase activity of other studied strains was not lower, and in some cases, higher than that of most of the drugs currently used in cholesterinosis.Документ Холестеразана активність молочнокислих бактерій in vitro та in vivo(2012) Старовойтова, Світлана ОлександрівнаДосліджено холестеразная активність бактерій родів Lactobacillus і Bifidobacterium та їх композицій у культуральному середовищі - in vitro і на експериментальній моделі гіперхолестеринемії у мишей - in vivo . Показано, що всі досліджені штами мають високу холестеразной активністю in vitro в межах 7,64-62,37 %. Вивчення холестеразной активності in vivo показало , що всі досліджені культури молочнокислих бактерій , а також їх композиції , крім L. bulgaricus ІМВ В- 7281 : B. bifidum VK -1 , проявляють гіпохестерінеміческую активність в середньому на рівні 14-63 % , що в більшості випадків , вище ніж для сучасних гіпохолестеринемічну препаратів. Cholesteraze activity of probiotic bacteria of genera Lactobacillus and Bifidobacterium and their compositions in the cultural medium – in vitro and on the experimental model of hypercholesterolemia in mice – in vivo was studied. It was shown, that all of the studied strains had high cholesteraze activity in vitro and ranged between 7.64–62.37 %. Study of cholesteraze activity in vivo was shown, that all of the studied lactic acid bacteria and their compositions, except L. bulgaricus ІМВ В-7281:B. bifidum VK-1, had hypocholesterolemic activity on average level 14–63 %, that in some cases higher than for modern hypocholesterolemic drugs.