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Документ Aminomethylation of formononetin and cladrin by primary amines(2009) Bondarenko, Svetlana; Frasinyuk, Mihaylo; Khilya, VolodimirThe reaction of natural isoflavones formononetin and cladrin with primary amines and formalin in the presence of a base catalyst was studied. Several novel substituted 9,10-dihydro-4H,8H-chromeno[8,7-e][1,3]oxazin-4-ones containing alkyl, benzyl, or heterylalkyl substituents in the N-9 position were synthesized.Документ Synthesis and properties of 4-(3-amino-2-benzofuranyl)-coumarins(2009) Frasinyuk, Mihaylo; Gorelov, S.; Bondarenko, Svetlana; Khilya, VolodimirThe alkylation of o-cyanophenol by 4-chloromethylcoumarins and subsequent intramolecular condensation by the cyano and methylene groups gives substituted 4-(3-amino-2-benzofuranyl) coumarins. We studied the reactions of these compounds with acylating agents as well as with aldehydes, which lead to the 6H-[1]benzofuro[3,2-b]chromeno[4,3-d]pyridin-6-one system as the result of consecutive transformations.Документ Synthesis and properties of 4-chloromethyl-6-hydroxycoumarins and 4-(2-benzofuryl)-6-hydroxycoumarins(2009) Frasinyuk, Mihaylo; Bondarenko, Svetlana; Khilya, VolodimirNew 4-chloromethyl-6-hydroxycoumarins have been obtained by the condensation of hydroquinone derivatives with 4-chloroacetoacetic ester, and have been used for the synthesis of 4-(2-benzofuryl)-6-hydroxycoumarins. Alkylation and acylation of the phenolic hydroxyl of the synthesized 4-(2-benzofuryl)coumarins have been investigated.Документ Reaction of analogs of natural isoflavonoids with amidines(2006) Frasinyuk, Mihaylo; Bondarenko, Svetlana; Khilya, VolodimirRecyclization of the chromone ring in a series of analogs of natural isoflavonoids by reaction with amidines was studied.Документ Synthesis of formononetin analogs(2003) Bondarenko, Svetlana; Frasinyuk, Mihaylo; Khilya, VolodimirDerivatives of the natural isoflavone formononetin were synthesized. Acylation and alkylation of the phenolic hydroxyls and the chromone ring were investigated.Документ Synthesis of 3',4'-dimethoxyisoflavone derivatives(2003) Bondarenko, Svetlana; Frasinyuk, Mihaylo; Khilya, Volodimir2-(Un)substituted-3',4'-dimethoxy-7-hydroxyisoflavones were synthesized. Their derivatives substituted at the phenolic hydroxyl were prepared by alkylation and acylation. Aminomethyl derivatives were also prepared.Документ Synthesis of pseudobaptigenin analogs(2003) Bondarenko, Svetlana; Frasinyuk, Mihaylo; Khilya, VolodimirHomologs of the natural isoflavonoid pseudobaptigenin containing benzodioxane and benzodioxepane fragments were synthesized. Methanesulfonyl, carbamoyl, aminomethyl, and coumarin-containing isoflavone derivatives were prepared.Документ Aminomethylation of 3-aryl-7-hydroxycoumarins(2010) Bondarenko, Svetlana; Frasinyuk, Mihaylo; Khilya, VolodimirThe reaction of the analogs of natural 3-arylbenzopyran-2-ones with electrophilic reagents of aminal structure was studied. Substituted 8-aminomethyl-3-aryl-7-hydroxycoumarins were synthesized. The optimum conditions were determined for the production of 9-alkyl- and 9-(het)arylmethyl derivatives of 3-aryl-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one in the series of analogs of natural 3-arylbenzopyran-2-ones.Документ Features of the aminomethylation of 7-hydroxy-4'-fluoroisoflavones with primary amines(2010) Bondarenko, Svetlana; Frasinyuk, Mihaylo; Khilya, VolodimirThe behavior of 7-hydroxy-4'-fluoroisoflavones under the conditions of the Mannich reaction with primary amines was studied. New 9-alkyl-substituted 3-(4-fluorophenyl)-9,10-dihydro-4H,8H-chromeno-[8,7-e][1,3]oxazin-4-ones were synthesized. A method was developed for the synthesis of 8-amino- methyl derivatives of isoflavones.